![]() Heparan Sulfate Analog (HSA), Retinol, Retinyl Safflowerate 100% of patients showed improved skin texture in 8 weeks 88% of patients showed improved skin smoothness and fine lines and wrinkles in 8 weeks Recommended for all skin types with signs of solar and environmental damage Improves the appearance of fine lines and wrinkles This is a remarkable, groundbreaking product line, and I give SENTÉ my highest recommendation.Non-Comedogenic, Dermatologist Tested, Paraben Free, No Animal Testing. I have experienced no irritation-in fact, the opposite-SENTÉ has been healing for my skin, as well as highly effective in tackling signs of aging. More than temporary, superficial changes, my skin also just feels and looks better. I noticed the first visible difference within just a few days of consistent application, and the results are still coming. With ongoing use, I am watching SENTÉ Bio Cellular Serum and Dermal Repair Cream tackle both sagging and wrinkles, almost like I am getting gradual internal “filler” in all those sagging, droopy spots and areas of entrenched wrinkles. By effectively creating hydration within, my skin is becoming plumped and firmer. Irritation and dryness are problems of the past. Result with no lasting improvement. The irritation-free results I am getting from SENTÉ Bio Complete Serum and Dermal Repair Cream surpass just about everythingĮlse I have tried (which is quite a collection). My skin tends to be pathologically dry, and SENTÉ is the first line ever to make a difference in my skin from the inside (rather than just a Most anti-aging strategies either completely backfire on skin like mine or offer some temporary Replenishing this vital molecule is likely to have a myriad of marked benefits for aging skin.īoth products are extremely light, quickly absorbed, and leave no residue behind. Remodeling, cell adhesion, immune function, and growth factor responsiveness. With age, our levels of heparan sulfate decline, and our skin sags, collagen becomes less organized, and wounds heal more slowly. Heparan sulfate also plays a major role in tissue For instance, heparan sulfate can bind and interact with extracellular matrix molecules, collagen types I, III, IV, and V, growth factors and cytokines (the basis of stem cell skin care lines), elastase, and much more (see Gallo, 2000). Heparan sulfate is present in all layers of skin and-due to its key actions in skin health and wound repair–has been termed a “master molecule” for skin. However, despite HA’s renown, it actually has far less biological activity than another GAG, heparan sulfate. When it comes to GAGs, most consumers will be most familiar with hyaluronic acid (HA), which holds a great deal of water, leading to its inclusion in countless skin care products as well as injectable fillers.
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